Description of the drug
Proviron (active ingredient - mesterolone) is a hormonal drug with moderate androgenic activity and significantly enhances erectile function. Proviron is often used in bodybuilding during the course of anabolic steroids for various tasks.
Among the well-known manufacturers of mesterolone are various branches of Schering (Proviron in the form of 25 mg tablets), the Moldovan Company Balkan Pharmaceuticals (Provimed, 50 mg tablets), Gerth Pharmaceuticals (Proviger, 50 mg tablets) and some others.
It is a weak aromatase inhibitor, that is, it slightly prevents the conversion of steroids into estrogens in the body. According to numerous reports from athletes, in practice, Proviron does not prevent gynecomastia, water retention, female fat deposition, and other estrogenic side effects.
Virtually no effect on the body's production of its own testosterone (in large doses it can suppress), but it helps to increase the concentration of free testosterone in the blood, due to the fact that it blocks the activity of sex hormone binding globulin. These properties make Proviron an attractive treatment during a cycle.
It is often used as part of post-cycle therapy, although the feasibility is questionable, since it lacks the ability to restore the secretion of endogenous testosterone.
How to take Proviron during a cycle
The usual daily dosage for men is 50 mg per day, divided into two equal doses, preferably after meals. A dosage of up to 100 mg of Proviron per day is considered acceptable. Higher doses of Proviron can lead to opposite effects than expected. With prolonged erection, which is often quite painful and uncomfortable, the dosage of the drug should be reduced or discontinued altogether.
Considering that the drug increases libido and improves potency in men, its use is justified on a course of drugs that lower libido (for example, when using nandrolone or trenbolone).
In addition, in bodybuilding, Proviron is often used in pre-competition training to increase the hardness of the muscles and give them relief. It is the favorite drug of Western film actors to give the appearance of muscularity, who are afraid to use heavier steroid "artillery". It is also used by women bodybuilders to give the muscles density, but their dosages should not exceed 25 mg per day for no more than four weeks to exclude the phenomenon of masculinization. Although professional bodybuilders do not adhere to these norms.
Improves the quality and increases the number of sperm. Compensates for the lack of production of male sex hormones (androgens), providing a stimulating effect on the development of male genital organs and secondary sexual characteristics, improves libido and potency, exhibits anabolic properties, stimulates erythropoiesis. Method of application: Inside, without chewing, 25 mg 1-3 times a day.
According to some reports, from studies, Proviron has shown itself well as an antidepressant. For the experiment, we took Masterolone and Amitriptyline. Both drugs have shown good results in improving mood. However, Masterolone turned out to be less toxic to the human body, with less number of side effects
It is not toxic to the liver in moderate doses, which makes it safe to take it during a cycle for several weeks. Does not suppress the hypothalamus-pituitary-testes axis. Due to its chemical nature and similarity to DHT, side effects such as prostate hypertrophy and male-pattern baldness are possible.
For the purpose of prevention, periodic examinations of the prostate gland are recommended. Caution when using After taking hormonal substances that make up the drug Proviron, the formation of benign, and even less often - malignant liver tumors was very rarely observed. In some cases, intra-abdominal bleeding caused by such tumors was life-threatening. If a man using Proviron has severe pain in the upper abdomen, an enlarged liver, or signs of intra-abdominal bleeding, the differential diagnosis should take into account the likelihood of a liver tumor.
Attenuation of the anabolic steroids action
Many authors, point to the use of Proviron and anabolic steroids (AS) of the same receptors, which supposedly reduces the effect of the latter. This information first appeared in Dan Duchaine's Underground Steroid Handbook II.
However, basic knowledge of pharmacokinetics allows us to refute this.
First, this antiestrogen is rapidly degraded in muscle to inactive metabolites.
Secondly, due to its high affinity for binding proteins (SHBG), the drug can increase the concentration of free AS, which increases the effectiveness of the course.
Choice of antiestrogens
The question of which antiestrogens drug should be preferred is often raised.
- Tamoxifen is a drug that blocks estrogen receptors, but does not interfere with estrogen production. Tamoxifen is more conducive to the restoration of its own testosterone, as it can directly affect the pituitary gland. Among the disadvantages - it slightly reduces the anabolic activity of steroid drugs. Applies only during PCT.
- Proviron increases the concentration of androgens by binding to SHBG, thus increasing the effectiveness of the course. However, Proviron, as shown in studies, does not contribute to the restoration of testosterone secretion, unlike tamoxifen. Repeatedly performed analyzes of the level of hormones showed that the antiestrogen effect of Proviron on the course is practically not manifested.
Considering the advantages and disadvantages of both drugs, the optimal course of steroids is structured as follows (relevant only for aromatized speakers):
1) Starting from the 2nd week of the course, Proviron is administered at a dose of 50 mg per day. Additionally, aromatase inhibitors should be used to control estrogen levels.
2) Immediately after the end of the course, Proviron is stopped and after steroids are removed from the body, tamoxifen is prescribed for 2-3 weeks at a dose of 10-20 mg per day.
- Side effects of steroids and how to reduce the harm of steroids
- Nolvadex or Clomid
- Best steroid courses